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The OGF–OGFr Axis Utilizes the p16<sup>INK4a</sup>and p21<sup>WAF1/CIP1</sup>Pathways to Restrict Normal Cell Proliferation

16 Oct 2008

Abstract excerpt

Opioid growth factor (OGF) is an endogenous opioid peptide ([Met(5)]enkephalin) that interacts with the OGF receptor (OGFr) and serves as a tonically active negative growth factor in cell proliferation of normal cells. To clarify the mechanism by which OGF inhibits cell replication in normal cells, we investigated the effect of the OGF-OGFr axis on cell cycle activity in human umbilical vein endothelial cells...

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PMID: 18923142
DOI: 10.1091/mbc.e08-07-0681

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