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Cell proliferation of human ovarian cancer is regulated by the opioid growth factor-opioid growth factor receptor axis

19 Mar 2009

Abstract excerpt

Ovarian cancer is the leading cause of death from gynecological malignancies. Understanding the biology of these tumors, as well as treatment modalities, has been challenging. The opioid growth factor (OGF; [Met(5)]-enkephalin) and the OGF receptor (OGFr) form an endogenous growth-regulating pathway in homeostasis and neoplasia. In this investigation, we examined the relationship of the OGF-OGFr axis to ovarian...

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PMID: 19297547
DOI: 10.1152/ajpregu.00075.2009

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