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Article

p53 and the Carcinogenicity of Chronic Inflammation.

Cold Spring Harbor perspectives in medicine - 1 Nov 2016

Gudkov Andrei V, Komarova Elena A

Abstract excerpt

Chronic inflammation is a major cancer predisposition factor. Constitutive activation of the inflammation-driving NF-κB pathway commonly observed in cancer or developed in normal tissues because of persistent infections or endogenous tissue irritating factors, including products of secretion by senescent cells accumulating with age, markedly represses p53 functions. In its turn, p53 acts as a suppressor of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27549311
DOI: 10.1101/cshperspect.a026161
PMCID: PMC5088512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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