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Article

p53-related apoptosis resistance and tumor suppression activity in UVB-induced premature senescent human skin fibroblasts

1 May 2008

Abstract excerpt

Chronic exposure to solar UV irradiation leads to photoaging, immunosuppression, and ultimately carcinogenesis. Cellular senescence is thought to play an important role in tumor suppression and apoptosis resistance. However, the relationships among stress-induced premature senescence (SIPS), tumorigenesis and apoptosis induced by UVB remain unknown. We developed a model of UVB-induced premature senescence in...

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PMID: 18425358
DOI: 10.3892/ijmm.21.5.645

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