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Article

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.

Cancer cell - 1 Aug 2005

Lee Sungwoo, Nakamura Eijiro, Yang Haifeng, Wei Wenyi, Linggi Michelle S, Sajan Mini P, Farese Robert V, Freeman Robert S, Carter Bruce D, Kaelin William G, Schlisio Susanne

Abstract excerpt

Germline NF1, c-RET, SDH, and VHL mutations cause familial pheochromocytoma. Pheochromocytomas derive from sympathetic neuronal precursor cells. Many of these cells undergo c-Jun-dependent apoptosis during normal development as NGF becomes limiting. NF1 encodes a GAP for the NGF receptor TrkA, and NF1 mutations promote survival after NGF withdrawal. We found that pheochromocytoma-associated c-RET and VHL...

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Source

Identifiers

PMID: 16098468
DOI: 10.1016/j.ccr.2005.06.015

Genes

NGF
RET
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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