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Article

Limited effects of frequent CYP2D636-10 tandem duplication allele on in vivo dextromethorphan metabolism in a Japanese population.

European journal of clinical pharmacology - 1 Oct 2010

Kiyotani Kazuma, Shimizu Makiko, Kumai Toshio, Kamataki Tetsuya, Kobayashi Shinichi, Yamazaki Hiroshi

Abstract excerpt

PURPOSE: although CYP2D6*36 was thought to be one of the alleles causing the poor metabolizer phenotype, several in vitro studies clarified that the enzyme produced by CYP2D6*36 showed enzymatic activities. However, the effects of CYP2D6*36 in tandem with CYP2D6*10 on the in vivo CYP2D6 activity have been unclear. In this study, we investigated in vivo metabolic capacities of CYP2D6 among the subjects carrying...

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Identifiers

PMID: 20700584
DOI: 10.1007/s00228-010-0876-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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