Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha.

The Journal of biological chemistry - 4 Oct 1996

Flodby P, Barlow C, Kylefjord H, Ahrlund-Richter L, Xanthopoulos K G

Abstract excerpt

CCAAT/enhancer binding protein alpha (C/EBPalpha) is a transcription factor that has been implicated in the regulation of cell-specific gene expression mainly in hepatocytes and adipocytes but also in several other terminally differentiated cells. It has been previously demonstrated that the C/EB...

Topics

Join the communities discussing this publication.

Phenotype
Mice
DNA-Binding Proteins
Cell Division
Transcription, Genetic
Nuclear Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8798745
DOI: 10.1074/jbc.271.40.24753

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8798745-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha.PMID 8798745Read ↗

CCAAT/enhancer binding protein alpha knock-in mice exhibit early liver glycogen storage and reduced susceptibility to hepatocellular carcinoma.Semantic proximity Read ↗

Roles of CCAAT/Enhancer-binding Proteins in Regulation of Liver Regenerative GrowthSemantic proximity Read ↗

Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha.Semantic proximity Read ↗

Metabolic response of mice to a postnatal ablation of CCAAT/enhancer-binding protein alpha.Semantic proximity Read ↗

Lung-specific inactivation of CCAAT/enhancer binding protein α causes a pathological pattern characteristic of COPDSemantic proximity Read ↗

CCAAT/enhancer binding protein alpha (C/EBPalpha) is an important mediator of mouse C/EBPbeta protein isoform production.Semantic proximity Read ↗

Respiratory Failure Due to Differentiation Arrest and Expansion of Alveolar Cells following Lung-Specific Loss of the Transcription Factor C/EBPα in MiceSemantic proximity Read ↗

Dysregulation of the C/EBPalpha differentiation pathway in human cancer.Semantic proximity Read ↗

Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver.Semantic proximity Read ↗

The C/EBP family of transcription factors in the liver and other organsSemantic proximity Read ↗

C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue.Semantic proximity Read ↗

Disruption of hepatic C/EBPalpha results in impaired glucose tolerance and age-dependent hepatosteatosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.