Article
Transgenic over-expression of GATA-1 mutant lacking N-finger domain causes hemolytic syndrome in mouse erythroid cells.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Jan 2005
Nakano Mayu, Ohneda Kinuko, Yamamoto-Mukai Harumi, Shimizu Ritsuko, Ohneda Osamu, Ohmura Sakie, Suzuki Mikiko, Tsukamoto Saho, Yanagawa Toru, Yoshida Hiroshi, Takakuwa Yuichi, Yamamoto Masayuki
Abstract excerpt
Transcription factor GATA-1 is essential for erythroid cell differentiation. GATA-binding motifs have been found in the regulatory regions of various erythroid-specific genes, suggesting that GATA-1 contributes to gene regulation during the entire process of erythropoiesis. A GATA-1 germ-line mutation results in embryonic lethality due to defective primitive erythropoiesis and GATA-1-null embryonic stem cells...
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