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Article

Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter.

Proceedings of the National Academy of Sciences of the United States of America - 24 Aug 2010

Peng Bailu, Ling Jianhua, Lee Andrew Joon, Wang Zilai, Chang Zhe, Jin Wei, Kang Ya'an, Zhang Richard, Shim David, Wang Huamin, Fleming Jason B, Zheng Hui, Sun Shao-Cong, Chiao Paul J

Abstract excerpt

Feedback regulation of transcription factor NF-kappaB by its inhibitor IkappaBalpha plays an essential role in control of NF-kappaB activity. To understand the biological significance of IkappaBalpha-mediated feedback regulation of NF-kappaB, we generated mice harboring mutated kappaB enhancers in the promoter of the IkappaBalpha gene (IkappaBalpha(M/M)) to inhibit NF-kappaB-regulated IkappaBalpha expression....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20696914
DOI: 10.1073/pnas.1005533107
PMCID: PMC2930541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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