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Clustering of dispersed ribosomal DNA and its role in gene regulation and chromosome-end associations in malaria parasites

9 Aug 2010

Abstract excerpt

Dynamic changes in gene positioning contribute to differential expression of virulence-related gene families in protozoan pathogens; however, the role of nuclear architecture in gene expression in the human malaria parasite Plasmodium falciparum remains poorly understood. Here we investigated the developmentally regulated ribosomal RNA (rRNA) gene family in P. falciparum, which, unlike that in most eukaryotes,...

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PMID: 20696894
DOI: 10.1073/pnas.1001045107

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