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Article

Sir2a regulates rDNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum.

Nature communications - 1 Jan 2013

Mancio-Silva Liliana, Lopez-Rubio Jose Juan, Claes Aurélie, Scherf Artur

Abstract excerpt

The Plasmodium falciparum histone deacetylase Sir2a localizes at telomeric regions where it contributes to epigenetic silencing of clonally variant virulence genes. Apart from telomeres, PfSir2a also accumulates in the nucleolus, which harbours the developmentally regulated ribosomal RNA genes. Here we investigate the nucleolar function of PfSir2a and demonstrate that PfSir2a fine-tunes ribosomal RNA gene...

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Identifiers

PMID: 23443558
DOI: 10.1038/ncomms2539
PMCID: PMC3586713

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