Article
Ex vivo cytokine and memory T cell responses to the 42-kDa fragment of Plasmodium falciparum merozoite surface protein-1 in vaccinated volunteers.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2008
Huaman Maria Cecilia, Martin Laura B, Malkin Elissa, Narum David L, Miller Louis H, Mahanty Siddhartha, Long Carole A
Abstract excerpt
A number of blood-stage malaria Ags are under development as vaccine candidates, but knowledge of the cellular responses to these vaccines in humans is limited. We evaluated the nature and specificity of cellular responses in healthy American volunteers vaccinated with a portion of the major merozoite surface protein-1 (MSP1) of Plasmodium falciparum, MSP1(42), formulated on Alhydrogel. Volunteers were vaccinated...
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