Article
Plasmodium falciparum merozoite surface protein 3 is a target of allele-specific immunity and alleles are maintained by natural selection.
The Journal of infectious diseases - 15 Jan 2007
Polley Spencer D, Tetteh Kevin K A, Lloyd Jennie M, Akpogheneta Onome J, Greenwood Brian M, Bojang Kalifa A, Conway David J
Abstract excerpt
BACKGROUND: Plasmodium falciparum merozoite surface protein (MSP) 3 is an asexual blood-stage malaria vaccine candidate antigen. Sequence polymorphisms divide alleles into 2 major types, but the adaptive and immunological significance of the types has not been defined. METHODS: One hundred one msp3 allele sequences were sampled from 2 populations living in areas where malaria is endemic and were analyzed for...
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