Article
Survival defects of Cryptococcus neoformans mutants exposed to human cerebrospinal fluid result in attenuated virulence in an experimental model of meningitis.
Infection and immunity - 1 Oct 2010
Lee Anthony, Toffaletti Dena L, Tenor Jennifer, Soderblom Erik J, Thompson J Will, Moseley M Arthur, Price Michael, Perfect John R
Abstract excerpt
Cryptococcus neoformans is a fungal pathogen that encounters various microenvironments during growth in the mammalian host, including intracellular vacuoles, blood, and cerebrospinal fluid (CSF). Because the CSF is isolated by the blood-brain barrier, we hypothesize that CSF presents unique stresses that C. neoformans must overcome to establish an infection. We assayed 1,201 mutants for survival defects in growth...
Topics
- Animals
- Bronchoalveolar Lavage Fluid
- Caenorhabditis elegans
- Cations, Monovalent
- Cattle
- Cell Line
- Cerebrospinal Fluid
- Cryptococcus neoformans
- Disease Models, Animal
- Fungal Proteins