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Article

Survival defects of Cryptococcus neoformans mutants exposed to human cerebrospinal fluid result in attenuated virulence in an experimental model of meningitis.

Infection and immunity - 1 Oct 2010

Lee Anthony, Toffaletti Dena L, Tenor Jennifer, Soderblom Erik J, Thompson J Will, Moseley M Arthur, Price Michael, Perfect John R

Abstract excerpt

Cryptococcus neoformans is a fungal pathogen that encounters various microenvironments during growth in the mammalian host, including intracellular vacuoles, blood, and cerebrospinal fluid (CSF). Because the CSF is isolated by the blood-brain barrier, we hypothesize that CSF presents unique stresses that C. neoformans must overcome to establish an infection. We assayed 1,201 mutants for survival defects in growth...

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Identifiers

PMID: 20696827
DOI: 10.1128/IAI.00551-10
PMCID: PMC2950369

Genes

NEDD8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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