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A Multi-Host Approach for the Systematic Analysis of Virulence Factors inCryptococcus neoformans

11 Aug 2014

Abstract excerpt

A multi-host approach was followed to screen a library of 1201 signature-tagged deletion strains of Cryptococcus neoformans mutants to identify previously unknown virulence factors. The primary screen was performed using a Caenorhabditis elegans-C. neoformans infection assay. The hits among these strains were reconfirmed as less virulent than the wild type in the insect Galleria mellonella-C. neoformans infection...

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PMID: 25114160
DOI: 10.1093/infdis/jiu441

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