Article
Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitors.
Genome biology - 1 Jan 2010
Jones Steven Jm, Laskin Janessa, Li Yvonne Y, Griffith Obi L, An Jianghong, Bilenky Mikhail, Butterfield Yaron S, Cezard Timothee, Chuah Eric, Corbett Richard, Fejes Anthony P, Griffith Malachi, Yee John, Martin Montgomery, Mayo Michael, Melnyk Nataliya, Morin Ryan D, Pugh Trevor J, Severson Tesa, Shah Sohrab P, Sutcliffe Margaret, Tam Angela, Terry Jefferson, Thiessen Nina, Thomson Thomas, Varhol Richard, Zeng Thomas, Zhao Yongjun, Moore Richard A, Huntsman David G, Birol Inanc, Hirst Martin, Holt Robert A, Marra Marco A
Abstract excerpt
BACKGROUND: Adenocarcinomas of the tongue are rare and represent the minority (20 to 25%) of salivary gland tumors affecting the tongue. We investigated the utility of massively parallel sequencing to characterize an adenocarcinoma of the tongue, before and after treatment. RESULTS: In the pre-treatment tumor we identified 7,629 genes within regions of copy number gain. There were 1,078 genes that exhibited...
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