Comprehensive Molecular Characterization of Salivary Duct Carcinoma Reveals Actionable Targets and Similarity to Apocrine Breast Cancer.

doi:10.1158/1078-0432.CCR-16-0637

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Article

Comprehensive Molecular Characterization of Salivary Duct Carcinoma Reveals Actionable Targets and Similarity to Apocrine Breast Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2016

Dalin Martin G, Desrichard Alexis, Katabi Nora, Makarov Vladimir, Walsh Logan A, Lee Ken-Wing, Wang Qingguo, Armenia Joshua, West Lyndsay, Dogan Snjezana, Wang Lu, Ramaswami Deepa, Ho Alan L, Ganly Ian, Solit David B, Berger Michael F, Schultz Nikolaus D, Reis-Filho Jorge S, Chan Timothy A, Morris Luc G T

Abstract excerpt

PURPOSE: Salivary duct carcinoma (SDC) is an aggressive salivary malignancy, which is resistant to chemotherapy and has high mortality rates. We investigated the molecular landscape of SDC, focusing on genetic alterations and gene expression profiles. EXPERIMENTAL DESIGN: We performed whole-exome sequencing, RNA sequencing, and immunohistochemical analyses in 16 SDC tumors and examined selected alterations via...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27103403
DOI: 10.1158/1078-0432.CCR-16-0637
PMCID: PMC5026550

Genes

ERBB2
HRAS
BRAF
FOXA1

Provenance

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