Article
The genomic road to invasion-examining the similarities and differences in the genomes of associated oral pre-cancer and cancer samples.
Genome medicine - 7 Jun 2017
Wood Henry M, Daly Catherine, Chalkley Rebecca, Senguven Burcu, Ross Lisa, Egan Philip, Chengot Preetha, Graham Jennifer, Sethi Neeraj, Ong Thian K, MacLennan Kenneth, Rabbitts Pamela, Conway Caroline
Abstract excerpt
BACKGROUND: It is frequently assumed that pre-invasive lesions are simpler precursors of cancer and will contain a limited subset of the genomic changes seen in their associated invasive disease. Driver mutations are thought to occur early, but it is not known how many of these are present in pre-invasive lesions. These assumptions need to be tested with the increasing focus on both personalised cancer treatments...
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