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Article

Structural and functional basis of resistance to neuraminidase inhibitors of influenza B viruses.

Journal of medicinal chemistry - 9 Sept 2010

Oakley Aaron J, Barrett Susan, Peat Thomas S, Newman Janet, Streltsov Victor A, Waddington Lynne, Saito Takehiko, Tashiro Masato, McKimm-Breschkin Jennifer L

Abstract excerpt

We have identified a virus, B/Perth/211/2001, with a spontaneous mutation, D197E in the neuraminidase (NA), which confers cross-resistance to all NA inhibitors. We analyzed enzyme properties of the D197 and E197 NAs and compared these to a D197N NA, known to arise after oseltamivir treatment. Zanamivir and peramivir bound slowly to the wild type NA, but binding of oseltamivir was more rapid. The D197E/N mutations...

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Identifiers

PMID: 20695427
DOI: 10.1021/jm100621s
PMCID: PMC2932999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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