Article
Peramivir susceptibilities of recombinant influenza A and B variants selected with various neuraminidase inhibitors.
Antiviral therapy - 1 Jan 2017
Fage Clément, Tu Véronique, Carbonneau Julie, Abed Yacine, Boivin Guy
Abstract excerpt
BACKGROUND: Peramivir is a parenteral neuraminidase inhibitor (NAI) approved for treating influenza infections in a few countries. We determined peramivir susceptibilities of several uncharacterized influenza A and B neuraminidase (NA) and haemagglutinin (HA) mutants selected with different NAIs. METHODS: Recombinant wild-type (WT) and mutant NA proteins were expressed in 293T cells and susceptibility to...
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