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Article

Early-life stress, corticotropin-releasing factor, and serotonin transporter gene: a pilot study.

Psychoneuroendocrinology - 1 Feb 2011

Coplan Jeremy D, Abdallah Chadi G, Kaufman Joan, Gelernter Joel, Smith Eric L P, Perera Tarique D, Dwork Andrew J, Kaffman Arie, Gorman Jack M, Rosenblum Leonard A, Owens Michael J, Nemeroff Charles B

Abstract excerpt

Recent studies have indicated a gene-by-environment interaction between serotonin transporter gene (5-HTTLPR) polymorphism and childhood abuse on depressive symptoms. In addition, persistent elevation of cerebrospinal fluid (CSF) corticotropin-releasing factor (CRF) concentrations following early...

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Identifiers

PMID: 20692103
DOI: 10.1016/j.psyneuen.2010.07.011
PMCID: PMC3017732

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20692103-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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