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Article

Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques.

Biological psychiatry - 1 Apr 2004

Barr Christina S, Newman Timothy K, Shannon Courtney, Parker Clarissa, Dvoskin Rachel L, Becker Michelle L, Schwandt Melanie, Champoux Maribeth, Lesch Klaus Peter, Goldman David, Suomi Stephen J, Higley J Dee

Abstract excerpt

BACKGROUND: In humans and macaques, a promoter polymorphism that decreases transcription of the serotonin transporter gene is associated with anxiety. Serotonin transporter gene disruption in rodents produces anxious animals with exaggerated limbic-hypothalamic-pituitary-adrenal (LHPA) responses to stress. We wanted to determine whether serotonin transporter gene promoter variation (rh-5HTTLPR) and rearing...

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PMID: 15039002
DOI: 10.1016/j.biopsych.2003.12.008

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