Article
Early-life stress, corpus callosum development, hippocampal volumetrics, and anxious behavior in male nonhuman primates.
Psychiatry research - 30 Apr 2011
Jackowski Andrea, Perera Tarique D, Abdallah Chadi G, Garrido Griselda, Tang Cheuk Y, Martinez Jose, Mathew Sanjay J, Gorman Jack M, Rosenblum Leonard A, Smith Eric L P, Dwork Andrew J, Shungu Dikoma C, Kaffman Arie, Gelernter Joel, Coplan Jeremy D, Kaufman Joan
Abstract excerpt
Male bonnet monkeys (Macaca radiata) were subjected to the variable foraging demand (VFD) early stress paradigm as infants, MRI scans were completed an average of 4 years later, and behavioral assessments of anxiety and ex-vivo corpus callosum (CC) measurements were made when animals were fully matured. VFD rearing was associated with smaller CC size, CC measurements were found to correlate with fearful behavior...
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