Article
Effect of huprine X on β-amyloid, synaptophysin and α7 neuronal nicotinic acetylcholine receptors in the brain of 3xTg-AD and APPswe transgenic mice.
Neuro-degenerative diseases - 1 Jan 2010
Hedberg Monika M, Clos M Victoria, Ratia Miriam, Gonzalez Daniel, Lithner Christina Unger, Camps Pelayo, Muñoz-Torrero Diego, Badia Albert, Giménez-Llort Lydia, Nordberg Agneta
Abstract excerpt
BACKGROUND: Several studies implicate acetylcholinesterase (AChE) in the pathogenesis of Alzheimer's disease (AD), raising the question of whether inhibitors of AChE also might act in a disease-modifying manner. Huprine X (HX), a reversible AChE inhibitor hybrid of tacrine and huperzine A, has shown to affect the amyloidogenic process in vitro. In this study, the aim was to investigate whether HX could affect the...
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