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Article

Effect of Acetylcholinesterase Inhibitors on the Cognitive Impairments in Transgenic Drosophila Model of Alzheimer’s Disease

2023-07-11

Abstract excerpt

Background: Alzheimer’s disease (AD) is characterized by neuronal loss, synaptic dysfunction, deposition of amyloid-beta (Aβ), and neurofibrillary tangles (NFTs). AD patients exhibit the loss of cholinergic neurons, leads to low levels of acetylcholine and increased activity of acetylcholinesterase which further reduces the levels of acetylcholine. It has now been established that acetylcholine plays a major role...

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Literature Corpus work
d1e9f332-3fb2-5aa8-b70f-3bc03d6f087b
DOI
10.2174/18741967-v11-e230704-2022-8
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