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Synthesis of novel hybrids of 1,2,3-triazoles-hydrazone: targeting cholinesterases and Alzheimer's related genes

12 Jun 2024

Abstract excerpt

Aim: A new series of 1,2,3-triazole-hydrazone derivatives were developed to evaluate their anti-Alzheimer's activity. Materials & methods: All compounds were screened toward cholinesterases via the modified Ellman's method. The toxicity assay on SH-SY5Y cells was performed using the MTT assay, and the expression levels of GSK-3α, GSK-3β, DYRK1 and CDK5 were assessed in the presence of compounds 6m and 6p....

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PMID: 38864182
DOI: 10.1080/17568919.2024.2359894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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