Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hematopoietic Stem Cell Expansion and Distinct Myeloid Developmental Abnormalities in a Murine Model of the <i>AML1</i> - <i>ETO</i> Translocation

28 Jul 2002

Abstract excerpt

The t(8;21)(q22;q22) translocation, which fuses the ETO gene on human chromosome 8 with the AML1 gene on chromosome 21 (AML1-ETO), is one of the most frequent cytogenetic abnormalities associated with acute myelogenous leukemia (AML). It is seen in approximately 12 to 15% of AML cases and is present in about 40% of AML cases with a French-American-British classified M2 phenotype. We have generated a murine model...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Hematopoietic Stem Cell Transplantation
Share to Protein Degradation and Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12101243
DOI: 10.1128/mcb.22.15.5506-5517.2002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hematopoietic Stem Cell Expansion and Distinct Myeloid Developmental Abnormalities in a Murine Model of the <i>AML1</i> - <i>ETO</i> TranslocationPMID 12101243Read ↗

Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice.Semantic proximity Read ↗

Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model.Semantic proximity Read ↗

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches.Semantic proximity Read ↗

AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocationSemantic proximity Read ↗

The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cellsSemantic proximity Read ↗

The ordered acquisition of Class II and Class I mutations directs formation of human t(8;21) acute myelogenous leukemia stem cell.Semantic proximity Read ↗

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations.Semantic proximity Read ↗

Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice.Semantic proximity Read ↗

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia.Semantic proximity Read ↗

Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor CellsSemantic proximity Read ↗

Defining the oncogenic function of the TEL/AML1 (ETV6/RUNX1) fusion protein in a mouse model.Semantic proximity Read ↗

Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.