Article
AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations.
Proceedings of the National Academy of Sciences of the United States of America - 28 Aug 2001
Yuan Y, Zhou L, Miyamoto T, Iwasaki H, Harakawa N, Hetherington C J, Burel S A, Lagasse E, Weissman I L, Akashi K, Zhang D E
Abstract excerpt
The t(8;21) is one of the most frequent chromosomal abnormalities associated with acute myeloid leukemia (AML). The translocation, which involves the AML1 gene on chromosome 21 and the ETO gene on chromosome 8, generates an AML1-ETO fusion transcription factor. To examine the effect of the AML1-ETO fusion protein on leukemogenesis, we made transgenic mice in which expression of AML1-ETO is under the control of...
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