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Article

Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense.

PLoS genetics - 29 Jul 2010

Hata Shoji, Abe Manabu, Suzuki Hidenori, Kitamura Fujiko, Toyama-Sorimachi Noriko, Abe Keiko, Sakimura Kenji, Sorimachi Hiroyuki

Abstract excerpt

Calpains constitute a superfamily of Ca2+-dependent cysteine proteases, indispensable for various cellular processes. Among the 15 mammalian calpains, calpain 8/nCL-2 and calpain 9/nCL-4 are predominantly expressed in the gastrointestinal tract and are restricted to the gastric surface mucus (pit) cells in the stomach. Possible functions reported for calpain 8 are in vesicle trafficking between ER and Golgi, and...

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Identifiers

PMID: 20686710
DOI: 10.1371/journal.pgen.1001040
PMCID: PMC2912385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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