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RNF213 modulates γ-herpesvirus infection and reactivation via targeting the viral Replication and Transcription Activator

14 Mar 2023

Abstract excerpt

Interferons (IFNs) and the products of interferon-stimulated genes (ISGs) play crucial roles in host defense against virus infections. Although many ISGs have been characterized with respect to their antiviral activity, their target specificities and mechanisms of action remain largely unknown. Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus that is linked to several human malignancies. Here,...

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PMID: 36917666
DOI: 10.1073/pnas.2218825120

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