Article
Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma.
Thorax - 1 Aug 2010
Kerkhof M, Postma D S, Brunekreef B, Reijmerink N E, Wijga A H, de Jongste J C, Gehring U, Koppelman G H
Abstract excerpt
BACKGROUND: Epidemiological studies have reported adverse effects of ambient air pollution on the prevalence of asthma. Laboratory studies have suggested that innate immune responses are involved. OBJECTIVE: A study was undertaken to determine whether the Toll-like receptor 2 and 4 genes (TLR2 and TLR4) influence the susceptibility to adverse effects of traffic-related air pollution with respect to the prevalence...
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