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Article

Toll-like Receptor 4 Pathway Polymorphisms Interact with Pollution to Influence Asthma Diagnosis and Severity.

Scientific reports - 23 Aug 2018

Schurman Shepherd H, Bravo Mercedes A, Innes Cynthia L, Jackson W Braxton, McGrath John A, Miranda Marie Lynn, Garantziotis Stavros

Abstract excerpt

Asthma is a common chronic lung disease, the incidence and severity of which may be influenced by gene-environment interactions. Our objective was to examine associations between single nucleotide polymorphisms (SNPs) and combinations of SNPs in the toll-like receptor 4 (TLR4) pathway, residential distance to roadway as a proxy for traffic-related air pollution exposure, and asthma diagnosis and exacerbations. We...

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Identifiers

PMID: 30140039
DOI: 10.1038/s41598-018-30865-0
PMCID: PMC6107668

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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