Childhood allergic rhinitis, traffic-related air pollution, and variability in the GSTP1, TNF, TLR2, and TLR4 genes: results from the TAG Study.

doi:10.1016/j.jaci.2013.03.007

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Article

Childhood allergic rhinitis, traffic-related air pollution, and variability in the GSTP1, TNF, TLR2, and TLR4 genes: results from the TAG Study.

The Journal of allergy and clinical immunology - 1 Aug 2013

Fuertes Elaine, Brauer Michael, MacIntyre Elaina, Bauer Mario, Bellander Tom, von Berg Andrea, Berdel Dietrich, Brunekreef Bert, Chan-Yeung Moira, Gehring Ulrike, Herbarth Olf, Hoffmann Barbara, Kerkhof Marjan, Klümper Claudia, Koletzko Sibylle, Kozyrskyj Anita, Kull Inger, Heinrich Joachim, Melén Erik, Pershagen Göran, Postma Dirkje, Tiesler Carla M T, Carlsten Chris

Abstract excerpt

BACKGROUND: Associations between traffic-related air pollution (TRAP) and allergic rhinitis remain inconsistent, possibly because of unexplored gene-environment interactions. OBJECTIVE: In a pooled analysis of 6 birth cohorts (Ntotal = 15,299), we examined whether TRAP and genetic polymorphisms related to inflammation and oxidative stress predict allergic rhinitis and sensitization. METHODS: Allergic rhinitis was...

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Identifiers

PMID: 23639307
DOI: 10.1016/j.jaci.2013.03.007

Genes

TLR4
TNF
GSTP1
TLR2

Provenance

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