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Article

BMPs and FGFs target Notch signalling via jagged 2 to regulate tooth morphogenesis and cytodifferentiation.

Development (Cambridge, England) - 1 Sept 2010

Mitsiadis Thimios A, Graf Daniel, Luder Hansueli, Gridley Thomas, Bluteau Gilles

Abstract excerpt

The Notch signalling pathway is an evolutionarily conserved intercellular signalling mechanism that is essential for cell fate specification and proper embryonic development. We have analysed the expression, regulation and function of the jagged 2 (Jag2) gene, which encodes a ligand for the Notch family of receptors, in developing mouse teeth. Jag2 is expressed in epithelial cells that give rise to the...

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Identifiers

PMID: 20685737
DOI: 10.1242/dev.049528
PMCID: PMC3114538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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