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Article

Different Roles of Runx2 During Early Neural Crest–Derived Bone and Tooth Development

1 Jul 2006

Abstract excerpt

UNLABELLED: We compared gene expression profiles between Runx2 null mutant mice and their wildtype littermates. Most Runx2-dependent genes in bones were different from those in teeth, implying that the target genes of Runx2 are tissue-dependent. In vitro experiments determined that Runx2 is a part of the FGF and BMP signaling pathways in tooth and bone development, respectively. INTRODUCTION: Runx2 (Cbfa1) is...

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PMID: 16813524
DOI: 10.1359/jbmr.060413

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