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Article

Notch Signaling Pathway in Tooth Shape Variations throughout Evolution.

Cells - 27 Feb 2023

Mitsiadis Thimios A, Pagella Pierfrancesco, Gomes Rodrigues Helder, Tsouknidas Alexander, Ramenzoni Liza L, Radtke Freddy, Mehl Albert, Viriot Laurent

Abstract excerpt

Evolutionary changes in vertebrates are linked to genetic alterations that often affect tooth crown shape, which is a criterion of speciation events. The Notch pathway is highly conserved between species and controls morphogenetic processes in most developing organs, including teeth. Epithelial loss of the Notch-ligand Jagged1 in developing mouse molars affects the location, size and interconnections of their...

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PMID: 36899896
DOI: 10.3390/cells12050761
PMCID: PMC10000876

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