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Article

Disuse-related decline in trabecular bone structure.

Biomechanics and modeling in mechanobiology - 1 Jun 2011

Akhter M P, Alvarez G K, Cullen D M, Recker R R

Abstract excerpt

Sedentary life style may degrade bone mass and microstructure resulting in osteoporosis. We characterized trabecular bone structural properties to determine if the LRP5 G171V mutation will protect against disuse-related bone loss. Forty-eight adult male mice representing three genotypes (WT = wild type, KO = LRP5-knockout +/-, HBM = High bone with the LRP5 G171V mutation) were each randomly divided between...

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Source

Identifiers

PMID: 20683635
DOI: 10.1007/s10237-010-0244-4

Genes

LRP5
HBM

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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