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Article

Trabecular Bone Deficit and Enhanced Anabolic Response to Re-Ambulation after Disuse in Perlecan-Deficient Skeleton.

Biomolecules - 29 Jan 2020

Parajuli Ashutosh, Pei Shaopeng, Zhao Hongbo, Martinez Jerahme R, Lu X Lucas, Liu X Sherry, Farach-Carson Mary C, Kirn-Safran Catherine B, Wang Liyun

Abstract excerpt

Perlecan/Hspg2, a large monomeric heparan sulfate proteoglycan, is found in the basement membrane and extracellular matrix, where it acts as a matrix scaffold, growth factor depot, and tissue barrier. Perlecan deficiency leads to skeletal dysplasia in Schwartz-Jampel Syndrome (SJS) and is a risk factor for osteoporosis. In the SJS-mimicking murine model (Hypo), inferior cortical bone quality and impaired...

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Identifiers

PMID: 32013135
DOI: 10.3390/biom10020198
PMCID: PMC7072656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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