Lrp4 Mediates Bone Homeostasis and Mechanotransduction through Interaction with Sclerostin In Vivo

Abstract excerpt

Wnt signaling plays a key role in regulating bone remodeling. In vitro studies suggest that sclerostin's inhibitory action on Lrp5 is facilitated by the membrane-associated receptor Lrp4. We generated an Lrp4 R1170W knockin mouse model (Lrp4 KI ), based on a published mutation in patients with high bone mass (HBM). Lrp4 KI mice have an HBM phenotype (assessed radiographically), including increased bone strength...

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