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Article

Genetic predisposition to low bone mass is paralleled by an enhanced sensitivity to signals anabolic to the skeleton.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2002

Judex Stefan, Donahue Leah-Rae, Rubin Clinton

Abstract excerpt

The structure of the adult skeleton is determined, in large part, by its genome. Whether genetic variations may influence the effectiveness of interventions to combat skeletal diseases remains unknown. The differential response of trabecular bone to an anabolic (low-level mechanical vibration) and a catabolic (disuse) mechanical stimulus were evaluated in three strains of adult mice. In low bone-mineral-density...

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Identifiers

PMID: 12153999
DOI: 10.1096/fj.01-0913fje

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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