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Article

Estimating the individualized HIV-1 genetic barrier to resistance using a nelfinavir fitness landscape.

BMC bioinformatics - 3 Aug 2010

Theys Kristof, Deforche Koen, Beheydt Gertjan, Moreau Yves, van Laethem Kristel, Lemey Philippe, Camacho Ricardo J, Rhee Soo-Yon, Shafer Robert W, Van Wijngaerden Eric, Vandamme Anne-Mieke

Abstract excerpt

BACKGROUND: Failure on Highly Active Anti-Retroviral Treatment is often accompanied with development of antiviral resistance to one or more drugs included in the treatment. In general, the virus is more likely to develop resistance to drugs with a lower genetic barrier. Previously, we developed a method to reverse engineer, from clinical sequence data, a fitness landscape experienced by HIV-1 under nelfinavir...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20682040
DOI: 10.1186/1471-2105-11-409
PMCID: PMC2921410

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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