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Article

Homo-oligomerization is the essential function of the tandem BRCT domains in the checkpoint protein Crb2.

The Journal of biological chemistry - 10 Sept 2004

Du Li-Lin, Moser Bettina A, Russell Paul

Abstract excerpt

BRCT (BRCA1 C terminus) domains are frequently found as a tandem repeat in proteins involved in DNA damage responses, such as Saccharomyces cerevisiae Rad9, human 53BP1 and BRCA1. Tandem BRCT domains mediate protein-protein and protein-DNA interactions. However, the functional significance of these interactions is largely unknown. Here we report the oligomerization of Schizosaccharomyces pombe checkpoint protein...

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Source

Identifiers

PMID: 15229228
DOI: 10.1074/jbc.M403326200

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Homo-oligomerization is the essential function of the tandem BRCT domains in the checkpoint protein Crb2.PMID 15229228Read ↗

Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair.Semantic proximity Read ↗

Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization.Semantic proximity Read ↗

BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint.Semantic proximity Read ↗

Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint.Semantic proximity Read ↗

BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligandsSemantic proximity Read ↗

Requirement for the phospho-H2AX binding module of Crb2 in double-strand break targeting and checkpoint activation.Semantic proximity Read ↗

Boundaries and physical characterization of a new domain shared between mammalian 53BP1 and yeast Rad9 checkpoint proteinsSemantic proximity Read ↗

Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks.Semantic proximity Read ↗

A superfamily of conserved domains in DNA damage‐ responsive cell cycle checkpoint proteinsSemantic proximity Read ↗

Tetrameric oligomerization mediates transcriptional repression by the BRCA1-dependent Kruppel-associated box-zinc finger protein ZBRK1.Semantic proximity Read ↗

Cooperative control of Crb2 by ATM family and Cdc2 kinases is essential for the DNA damage checkpoint in fission yeast.Semantic proximity Read ↗

Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivitySemantic proximity Read ↗

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