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Article

Histone variant H3.3 is an essential maternal factor for oocyte reprogramming

5 May 2014

Abstract excerpt

Mature oocyte cytoplasm can reprogram somatic cell nuclei to the pluripotent state through a series of sequential events including protein exchange between the donor nucleus and ooplasm, chromatin remodeling, and pluripotency gene reactivation. Maternal factors that are responsible for this reprogramming process remain largely unidentified. Here, we demonstrate that knockdown of histone variant H3.3 in mouse...

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PMID: 24799717
DOI: 10.1073/pnas.1406389111

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