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Article

Real-time monitoring of replication errors' fate reveals the origin and dynamics of spontaneous mutations.

Nature communications - 27 Mar 2024

Enrico Bena Chiara, Ollion Jean, De Paepe Marianne, Ventroux Magali, Robert Lydia, Elez Marina

Abstract excerpt

The efficiency of replication error repair is a critical factor governing the emergence of mutations. However, it has so far been impossible to study this efficiency at the level of individual cells and to investigate if it varies within isogenic cell populations. In addition, why some errors escape repair remains unknown. Here we apply a combination of fluorescent labelling of the Escherichia coli Mismatch...

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Identifiers

PMID: 38538613
DOI: 10.1038/s41467-024-46950-0
PMCID: PMC10973407

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