Dual-specificity phosphatase 1 as a pharmacogenetic modifier of inhaled steroid response among asthmatic patients.

doi:10.1016/j.jaci.2010.06.007

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Article

Dual-specificity phosphatase 1 as a pharmacogenetic modifier of inhaled steroid response among asthmatic patients.

The Journal of allergy and clinical immunology - 1 Sept 2010

Jin Ying, Hu Donglei, Peterson Edward L, Eng Celeste, Levin Albert M, Wells Karen, Beckman Kenneth, Kumar Rajesh, Seibold Max A, Karungi Gloria, Zoratti Amanda, Gaggin John, Campbell Janis, Galanter Joshua, Chapela Rocío, Rodríguez-Santana José R, Watson H Geoffrey, Meade Kelley, Lenoir Michael, Rodríguez-Cintrón William, Avila Pedro C, Lanfear David E, Burchard Esteban G, Williams L Keoki

Abstract excerpt

BACKGROUND: Inhaled corticosteroids (ICSs) are considered first-line treatment for persistent asthma, yet there is significant variability in treatment response. Dual-specificity phosphatase 1 (DUSP1) appears to mediate the anti-inflammatory action of corticosteroids. OBJECTIVE: We sought to determine whether variants in the DUSP1 gene are associated with clinical response to ICS treatment. METHODS: Study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20673984
DOI: 10.1016/j.jaci.2010.06.007
PMCID: PMC2943151

Genes

DUSP1
FEV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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