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Article

Genome-wide interaction study reveals age-dependent determinants of responsiveness to inhaled corticosteroids in individuals with asthma.

PloS one - 1 Jan 2020

Dahlin Amber, Sordillo Joanne E, McGeachie Michael, Kelly Rachel S, Tantisira Kelan G, Lutz Sharon M, Lasky-Su Jessica, Wu Ann Chen

Abstract excerpt

While genome-wide association studies have identified genes involved in differential treatment responses to inhaled corticosteroids (ICS) in asthma, few studies have evaluated the potential effects of age in this context. A significant proportion of asthmatics experience exacerbations (hospitalizations and emergency department visits) during ICS treatment. We evaluated the interaction of genetic variation and age...

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Identifiers

PMID: 32119686
DOI: 10.1371/journal.pone.0229241
PMCID: PMC7051058

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