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Article

Functional significance of the GAG trinucleotide-repeat polymorphism in the gene for the catalytic subunit of gamma-glutamylcysteine ligase.

Free radical biology & medicine - 1 Sept 2008

Nichenametla Sailendra N, Ellison Irina, Calcagnotto Ana, Lazarus Philip, Muscat Josh E, Richie John P

Abstract excerpt

Gamma-glutamylcysteine ligase (GCL) is the rate-limiting enzyme in glutathione (GSH) synthesis. A GAG-repeat polymorphism in the 5' UTR of the gene coding for the catalytic subunit of GCL (GCLC) has been associated with altered GSH levels in vitro. Thus, we hypothesized that this polymorphism is associated with altered GCL activity and blood GSH levels in vivo. A total of 256 healthy United States black and white...

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Identifiers

PMID: 18549827
DOI: 10.1016/j.freeradbiomed.2008.05.012
PMCID: PMC2562218

Genes

GCLC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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