Article
Transforming growth factor-beta receptor-3 is associated with pulmonary emphysema.
American journal of respiratory cell and molecular biology - 1 Sept 2009
Hersh Craig P, Hansel Nadia N, Barnes Kathleen C, Lomas David A, Pillai Sreekumar G, Coxson Harvey O, Mathias Rasika A, Rafaels Nicholas M, Wise Robert A, Connett John E, Klanderman Barbara J, Jacobson Francine L, Gill Ritu, Litonjua Augusto A, Sparrow David, Reilly John J, Silverman Edwin K
Abstract excerpt
Chronic obstructive pulmonary disease (COPD) is a heterogeneous syndrome, including emphysema and airway disease. Phenotypes defined on the basis of chest computed tomography (CT) may decrease disease heterogeneity and aid in the identification of candidate genes for COPD subtypes. To identify these genes, we performed genome-wide linkage analysis in extended pedigrees from the Boston Early-Onset COPD Study,...
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