Article
Polymorphism of SERPINE2 gene is associated with pulmonary emphysema in consecutive autopsy cases.
BMC medical genetics - 10 Nov 2010
Fujimoto Koichi, Ikeda Shinobu, Arai Tomio, Tanaka Noriko, Kumasaka Toshio, Ishii Takeo, Kida Kozui, Muramatsu Masaaki, Sawabe Motoji
Abstract excerpt
BACKGROUND: The SERPINA1, SERPINA3, and SERPINE2 genes, which encode antiproteases, have been proposed to be susceptible genes for of chronic obstructive pulmonary disease (COPD) and related phenotypes. Whether they are associated with emphysema is not known. METHODS: Twelve previously reported single nucleotide polymorphisms (SNPs) in SERPINA1 (rs8004738, rs17751769, rs709932, rs11832, rs1303, , and...