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Article

Association of genetic variation in cystathionine-beta-synthase and arsenic metabolism.

Environmental research - 1 Aug 2010

Porter Kristin E, Basu Anamika, Hubbard Alan E, Bates Michael N, Kalman David, Rey Omar, Smith Allan, Smith Martyn T, Steinmaus Craig, Skibola Christine F

Abstract excerpt

Variation in individual susceptibility to arsenic-induced disease may be partially explained by genetic differences in arsenic metabolism. Mounting epidemiological evidence and in vitro studies suggest that methylated arsenic metabolites, particularly monomethylarsonic (MMA3), are more acutely toxic than inorganic arsenic; thus, MMA3 may be the primary toxic arsenic species. To test the role of genetic variation...

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Source

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Identifiers

PMID: 20670920
DOI: 10.1016/j.envres.2010.05.001
PMCID: PMC2913479

Genes

CBS
DHFR
GSTO1
MTHFR
MTR
SHMT1
TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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